JUVÉDERM® is an injectable gel made of hyaluronic acid, which occurs naturally in your skin, that helps to add volume and hydration. JUVÉDERM® injectable gel is placed under the skin to restore your skin’s volume, smoothing away facial wrinkles and folds. Juvederm is commonly used to treat “smile lines” or “parentheses” (nasolabial folds – the creases that run from the bottom of your nose to the corners of your mouth).